Sanibel Island Luxury Rentals - Vacation Rentals in Main Street Studio

Now booking for Spring/Summer, 2026 From US $319
         

10.0 (117 Reviews)
House
  • Air Conditioner
  • Parking
  • Pet Friendly
Mad House From US $234
         

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7.0 (1 Review)
House
  • Parking
  • Child Friendly
  • Internet
Mad River Inn From US $184
         

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10.0 (45 Reviews)
Bed & Breakfast
  • Air Conditioner
  • Parking
  • Designated Smoking Area
The Featherbed Inn & Nordic Spa From US $240
         

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9.7 (20 Reviews)
Bed & Breakfast
  • Air Conditioner
  • Parking
  • TV
The Featherbed Inn & Nordic Spa From US $216
         

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9.8 (51 Reviews)
Bed & Breakfast
  • Air Conditioner
  • Parking
  • Pool
Rare deluxe 1 bdrm w/views of the Covered Bridge From US $189
         

10.0 (14 Reviews)
Apartment
  • Air Conditioner
  • Security/Safety
  • Bedding/Linens
Historic Valley View From US $359
         

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9.4 (7 Reviews)
House
  • Air Conditioner
  • Balcony/Terrace
  • Security/Safety
The Inn at Round Barn Farm From US $215
         

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9.4 (182 Reviews)
Bed & Breakfast
  • Air Conditioner
  • Parking
  • Balcony/Terrace
Private 5BR mt. view, pool, new hot tub, & fireplace! From US $882
         

Beautiful Family Home Central to Mad River Valley From US $374
         

10.0 (12 Reviews)
House
  • Air Conditioner
  • Parking
  • Pet Friendly
A-Frame Resto-Mod: Built in '73, Restored in '23 From US $452
         

10.0 (6 Reviews)
Ski Chalet
  • Pet Friendly
  • TV
  • Security/Safety
New Modern Mountain Retreat From US $849
         

10.0 (4 Reviews)
House
  • Air Conditioner
  • Parking
  • TV
Historic Vermont Farmhouse Minutes to Skiing From US $1,117
         

10.0 (1 Review)
House
  • Parking
  • Pet Friendly
  • Balcony/Terrace
Butternut at Sugarbush From US $286
         

10.0 (1 Review)
Apartment
  • Parking
  • Pool
  • TV
Pro Tip: Sanibelislandluxuryrentals makes it easy to compare the best listings on Sanibelislandluxuryrentals homes from online vacation rental OTAs, including Booking.com and more. Use the Advanced Filter feature at the top to easily flip between Sanibelislandluxuryrentals homes, vacation rentals, bed and breakfasts, private Airbnb-style rentals availability, eco-friendly properties, property type, cancellation policies, prices, and several different options. All these make it easier to find the perfect accommodation for your next vacation in Main Street Studio.

Weather in Main Street Studio

View the weather forecast for Main Street Studio before booking your Main Street Studio Vacation Rentals to confirm your best time to go.

December - February
High 60°F       Low 26°F
March - May
High 77°F       Low 40°F
June - August
High 91°F       Low 64°F
September - November
High 84°F       Low 38°F

Main Street Studio Vacation Rental Frequently Asked Questions

What are the top vacation rentals in Main Street Studio?
How many vacation rentals are available in Main Street Studio?

Currently, the total number of properties listed in 2026 is over 112 in the Main Street Studio area, and still counting. By aggregating listings from multiple websites, offers an immense amount of choice of the best properties in Main Street Studio.